National Heart, Lung, and Blood Institute
CENTER FOR FETAL MONKEY GENE TRANSFER FOR
HEART, LUNG, AND BLOOD DISEASES
 
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Annual Gene Therapy Symposium
California National Primate Research Center
Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases: A NHLBI Resource for the Gene Therapy Community
National Heart, Lung, and Blood Institute
NHLBI Scientific Resources
American Society of Gene and Cell Therapy
Gene Therapy Resource Program
UC Davis
One UC Davis
 

Goals and Mission

The goals of the Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases are to: (1) conduct studies in monkeys to evaluate the safety and efficiency of gene therapy strategies as they emerge; and (2) provide NHLBI-funded investigators with essential expertise, resources, and services to actively pursue gene transfer approaches with rhesus monkeys in their research programs. The overriding objective is to fulfill the mission of collaborative opportunities for NHLBI-supported investigators in order to explore crucial questions in gene delivery in a relevant preclinical primate model.

The NHLBI Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases is a unique resource that has served a crucial role in the gene therapy community by addressing essential questions in gene delivery and providing investigators with opportunities to test new vector constructs and approaches that advance the field. Any investigator funded by the NHLBI is eligible to submit a Letter of Intent and apply through a competitive process to conduct studies with monkeys. Since inception in 2001, the Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases has conducted over 45 projects for investigators across the U.S. (e.g., Childrens Hospital Los Angeles, City of Hope, George Washington University, Harvard University, St. Jude Children’s Research Hospital, Stanford University, UCLA, UCSF, University of Florida, University of North Carolina at Chapel Hill, University of Pennsylvania, Washington University at St. Louis). The established infrastructure can rapidly test new paradigms, move new hypotheses and emerging gene transfer vectors into a preclinical setting, and provide critical preliminary data for new NIH grants and IND submissions. Each aspect of the clinical development plan for studies that were conducted to meet the FDA requirements for human clinical trials was facilitated by interactions with the program, and showed substantial support for the research community in addressing regulatory barriers. The leap from preclinical discovery to human subject research is challenging, and the Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases is a crucial component in this process.

 


 

 
 
Home  |  About the Center  |  Call for Letters of Intent  |  Services Offered to Grantees
Funded Projects  |  Related Links  |  Contact